A discussion is provided of key elements in the success of cooperative programs between high schools and colleges. First, traditional approaches to collaboration, such as the the development of high school courses by university teachers, are reviewed; differences in the cultures of the high school and the college are specified; and the broad range of options available to educators who are willing to accept the need for structural reform and to use the needs of the student as a guide is introduced. Next, the paper looks at factors that are important to successful collaboration, including: (1) the identification of a faculty member with a sense of mission and established credibility to design a realistic program which can gain the approval of authorities at each level of the system; and (2) the development of a program which offers benefits to both institutions. Then, the paper discusses the need for structural changes to ensure effective collaboration, focusing on mastery learning, lowered student/faculty ratios, limited school size, design of courses for the average as well as the exceptional student, and the inclusion of remedial programs within the curriculum. The final sections specify methods of enhancing the high school/college relationship, and the optimum methods of program evaluation. (HB)